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  • There are many reasons why you should be supplementing with this essential nutrient, Coq10 – particularly if taking statins

There are many reasons why you should be supplementing with this essential nutrient, Coq10 – particularly if taking statins

Coenzyme Q10 (CoQ10) performs two major roles in the body – energy production and antioxidant protection. Found in the mitochondria of the body’s cells, CoQ10 helps to generate adenosine triphosphate (ATP), which is the body’s energy currency. CoQ10 is also found in high concentrations in the heart, liver, kidneys and pancreas – all of which are the organs with the highest energy needs.

CoQ10 generates energy in its oxidized form, called ubiquinone, and it also produces ubiquinol, its reduced form, which acts as a powerful antioxidant. Ubiquinol scavenges free radicals, helping to protect proteins, low-density lipoprotein (LDL, a cholesterol transporter) and DNA from oxidative damage.

COQ10 DEFICIENCY

CoQ10 benefitsThe body only makes a small amount of CoQ10 and, as we age, we begin to lose our natural ability to synthesize this enzyme. It can also be very hard to get directly from food. A deficiency of CoQ10 can mean that the body’s cells may not have enough energy to function properly and you will become more vulnerable to free radical damage that could lead to disease.

Ageing isn’t the only reason why our CoQ10 levels drop – taking medication such as statins has been shown to reduce CoQ10 levels too. This is why many people end up with muscle aches and weakness while taking statins. A study in The Journal of Clinical Pharmacology showed statins decrease serum CoQ10 levels up to 40%. Other drugs that can reduce levels of CoQ10 include beta-blockers, antidepressants, diuretics, anti-diabetic medications and psychotherapeutic medications.

The following symptoms may be a sign that you have deficient CoQ10 levels:

  • Gum or periodontal disease

  • Hypertension

  • Arteriosclerosis, atherosclerosis

  • Angina, arrhythmia or congestive heart failure

  • Stomach (gastric) or duodenal ulcers

  • High blood sugar

  • Kidney or renal failure

  • A weak immune system leading to susceptibility to infections

THE BENEFITS OF COQ10

CoQ10s antioxidant action has been found to help combat lipid peroxidation, which damages LDL and contributes to the development of atherosclerosis, hardening of the arteries,. Australian researchers discovered that 100mg of CoQ10 significantly increases LDL- ubiquinol concentration, thus potentially inhibiting LDL oxidation.1

CoQ10 has also been found to improve blood pressure. Researchers from the University of Florence Medical School found that when patients with essential hypertension were given 50mg of CoQ10 twice daily for 10 weeks, they experienced a significant decrease in peripheral resistance and blood pressure.2

And CoQ10 can also help people with type 2 diabetes. Researchers from the University of Western Australia found that a 100mg twice daily dose of CoQ10 helped improve blood pressure and long- term glycemic control.3

WHICH FORM IS BEST?

Generally speaking Co10 is poorly absorbed by the body because its crystalline structure doesn’t fully dissolve in the gastrointestinal tract. However, hydrosoluble CoQ10 dissolves in water, making it easier for the body to absorb. Also, studies show that hydrosoluble CoQ10 is more efficient in increasing ubiquinone levels.4

As mentioned above, CoQ10 comes in two forms – ubiquinone and ubiquinol.

Ubiquinone is the completely oxidized form of CoQ10 and, when taken, it is metabolized within our bodies where it becomes ubiquinol – the antioxidant form of CoQ10. As we age, our ability to metabolize is reduced over time, which is why it becomes more difficult for the body to break down ubiquinone into ubiquinol. Therefore, with age, it is best to choose ubiquinol in order to gain the best benefits from your CoQ10 supplementation.

 

RECOMMENDED PRODUCTS

UB8Q10
 
Also known as Ubiquinol, that is a co-enzyme Q10 that is eight times better absorbed compared to ordinary CoQ10!
 
UB8Q10 Ubiquinol

 

References
1. Thomas SR, Neuzil J, Stocker R. Inhibition of LDL oxidation by ubiquinol-10. A protective mechanism for coenzyme Q in atherogenesis? Molecular Aspects of Medicine. 1997.(18) 1: 85-103.

2. Digiesi V, Cantini F, Oradei A, Bisi G, Guarino GC, Brocchi A, Bellandi F, Mancini M, Littarru GP. Coenzyme Q10 in essential hypertension. Molecular Aspects of Medicine. 1994. 15 (1) 257-263.

3. Hodgson JM, Watts GF, Playford DA, Burke V and Croft KD. Coenzyme Q10 improves blood pressure and glycaemic control: a controlled trial in subjects with type 2 diabetes. 2002. European Journal of Clinical Nutrition. 56, 1137–1142.

4. Bergamini C, Moruzzi N, Sblendido A, Lenaz G, Fato R. A Water Soluble CoQ10 Formulation Improves Intracellular Distribution and Promotes Mitochondrial Respiration in Cultured Cells. PLoS One 2012;7(3):e33712.